"I believe we will play (at Old Trafford) with two strikers because it is a game we want to win," Wenger said on Arsenal's official website on Friday.
"We are in a position where one point is not good enough and psychologically we are in a different situation (to Europe)."
The Frenchman deploys Thierry Henry as a lone striker in Europe as Arsenal play with a 4-5-1 formation that helped the Gunners shoot down big names like Spain's Real Madrid and Italian Champions Juventus.
But Wenger said that this formation doesn't work effectively in the Premiership.
"We play nearly always in the Premiership with a 4-4-2, I tried it (4-5-1) but it didn't work too much," he said.
"We have an attacking style, mainly through the centre. Thierry occasionally plays only there but most of the time he moves around and goes wide so you need another striker more central."
Arsenal are fifth in the Premiership table with 53 points and one match in hand while Manchester hold the second place on 72.