كتب : Mohamed Sabe
Goals from Iyad Mando and Ahmed Al-Omeir put Al-Karama at level with Ittihad, who won the first-leg in Jeddah 2-0.
But the Asian champions were stunned by a double from Mohanad Ibrahim in overtime to exit the competition with a 4-2 aggregate defeat.
Al-Karama, who became the first Syrian team to reach the competition semis, will face Kuwaiti side Al-Qadsia who eliminated former champions Al-Ain of UAE.
Al-Qadsia crushed the Emirates counterparts 3-0 in the second-leg, courtesy of a Fouzi Basheer double and a Mohamed Mubarak strike to qualify with a 5-2 aggregate win.
Al-Karama will host Al-Qadsia in the first leg of the semis on September 27th, while Ulsan Hyundai Horang-I, who eliminated Saudi champions Al-Shabab, will face South Korean counterparts Jeonbuk Motors.