كتب : Amr Fahmy
Egyptian striker Mido flicked on a pin-pointed header that fell to Irishman Robbie Keane who smashed home brilliant volley, firing the Spurs ahead after seven minutes.
Mido almost scored an own goal in the 40th minute but his header was brilliantly saved by England international Paul Robinson
In the second period, Mido and Keane produced a carbonic copy from the first goal putting the visitors two goals up.
Fulham's German right-back Moritz Volz fired a left-footed strike only to be tipped away by Robinson who kept a clean sheet.
Mido's part was ended in the game as Bulgarian marksman Dimitar Berbatov took his place in the 73rd minute.
Collins John went close for Fulham after being put through by Senegalese midfielder Bouba Diop, but the Dutchman's effort went over the bar.
In the 78th minute Berbatov made an impact, adding the Spurs' third goal on the rebound after a low drive bounced from the post.
Egyptian midfielder Hossam Ghaly saw some action as he came in for English international Aaron Lennon in the 82nd minute.
Keane put a magnificent pass that broke the offside trap to see Berbatov who slotted in with a cool finish past Czech keeper Jan Lastuvka in 90 minutes.
Italian substitute Vincenzo Montella was sent off in the stoppage time after elbowing man of the match Keane.