كتب : Hatem Maher
Spurs, who booked a last-eight berth after defeating Portugal's Sporting Braga 6-4 on aggregate, are aiming to grab their first piece of silverware under coach Martin Jol as well as winning their third UEFA Cup title in history.
Sevilla survived a scare against Ukrainian side Shakhtar Donetsk to progress to the quarter-finals and remain on course of a second successive triumph.
Either Tottenham or Sevilla will face the winners of Osasuna-Bayer Leverkusen tie in the competition's semi-finals.
Espanyol were paired with Portuguese giants Benfica while Dutch side AZ Alkmaar take on Germany's Werder Bremen.