كتب : Hatem Maher
Al Shabab defender Hassan Maaz scored in his own net in the 33rd minute to give the hosts the victory before being sent-off six minutes from time.
Egyptian defender Azmi is still missing as he has been left out of the team's squad by Al-Shabab's Portuguese coach Jose De Morias.
Sepahan booked their place in the quarter-finals as they top Group D with 13 points, three ahead of the Saudi outfit who have been officially eliminated.
Elsewhere, Al-Karama of Syria have reached the last eight following a 2-0 home victory over Uzbekistan club Neftchi, thanks to Iyad Mando's brace.
Al-Karama are in charge of Group C on 11 points, one ahead of Neftchi to secure passage to the quarter-finals.