The Jordan defender, who signed from Faisali last summer, has been rarely selected by Krol since the first day 1-0 defeat to Ismaili.
Saad's inclusion comes at the expense of Tunisian stopper Yamen Ben Zekri.
Injured duo Alaa Abdul-Ghani and Hazem Emam failed to make the squad, while under-fire striker Amr Zaki is serving a 2-week ban by the club.
Zamalek are in fourth place with 17 points in the Egyptian league, trailing leaders Al-Gaish by six points.
Zamalek Squad
Goalkeepers: Mohamed Abdul-Monsef, Abdul-Wahed Al-Sayed
Defenders: Ahmed Ghanem, Wissem El-Abdi, Beshir Al-Tabie, Mahmoud Fathallah, Amr Al-Safti, Khaled Saad, Tarek Al-Sayed.
Midfielders: Magdi Attwa, Tamer Abdul-Hamid, Ahmed Magdi, Ahmed Abdul-Raouf, Mohamed Aboul-Ella, Mahmoud Abdul-Razek (Shikabala)
Strikers: Sherif Ashraf, Abdul-Halim Ali, Mostafa Gaafar, Gamal Hamza