Egypt coach Hassan Shehata has also omitted ENPPI striker Ahmed Raouf and Ahli's Sayed Moawad and Hossam Ashour.
The five players were included in the team that lost 4-1 to Sudan in a friendly in August.
Shehata introduced six new players with Ismaili's Mohamed Sobhi and Mohamed 'Hommos' Soliman making their international comeback alongside Ahli defender Ahmed Al-Sayed and Ghazl Mahalla's Mohsen Hendawi.
Ittihad's young keeper Al-Hani Soliman and Masri left-winger Ahmed Shedid will also get the chance to deputize for Egypt in Kinshasa.
Egypt's Full squad to face DR Congo:
Goalkeepers: Essam Al-Hadari (FC Sion – Switzerland), Amir Abdul-Hamid (Ahli), Al-Hani Soliman (Ittihad).
Defenders: Hani Saied, Mahmoud Fathallah (Zamalek), Wael Gomaa, Ahmed Al-Sayed (Ahli), Mohsen Hendawi (Ghazl Mahalla), Ahmed Samir Farag (Ismaili), Ahmed Shedid (Masri), Ahmed Al-Muhammadi (ENPPI).
Midfielders: Ahmed Hassan, Mohamed Abu-Treika (Ahli), Hosni Abd-Rabou (Ahli Dubai), Ahmed Shaaban (Petrojet), Ahmed Eid (Harras Al-Hodoud), Mohamed 'Hommos' Soliman (Ismaili).
Strikers: Amr Zaki (Wigan Athletic), Ahmed Hossam 'Mido' (Middlesbrough), Emad Meteb (Ittihad Jeddah), Mohamed Fadl (Ismaili).