The Whites have to focus on their local campaign as they are eighth of the Egyptian table with seven points
However they still have two games in hand and they could go clear at the top if they beat Telecom Egypt and Tersana.
"We must put aside our African debacle and focus on our local campaign. We must win those games to get back on track. All the players are very determined and motivated," Captain Ayman Abdul-Aziz told the club's website.
Coach Reiner Hollmann will have to do without injured Hani Saied and Mohamed Ibrahim while Shikabala and Mohamed Aboul-Ella are still purging their suspensions.
On the other hand Telecom Egypt enjoyed a bright start to their campaign as they are now third with 10 points just one behind leaders Petrojet.
"We are targeting the three points to maintain our good start. My men are ready and confident that we can beat Zamalek," coach Helmi Toulan told FilGoal.com.
Telecom Egypt will be without two of their best men as defenders Wael al-Qabani and Mahmoud Mahmoud won't be able to play against their former club because of injuries.
Sunday's match is guaranteed to provide its fair share of drama but Hollmann can't afford any more setbacks after being given three votes of confidence since taking over in June.