كتب : Hatem Maher
The draw, which was held on Thursday, did not feature any game between two Premier League teams.
Zamalek's arch-rivals Ahli were paired with Alexandria-based club Koroum.
Ismaili face Dakhileya while last season's runners-up ENPPI take on Bani Swaif Telephones.
Masri tackle Shams, Ghazl Mahalla meet city rivals Baladeya and Ittihad face Mansoura.
Current league leaders Petrojet meet second-division club Gendi.
All the matches will be played within the last 11 days of December. The cup rounds will not witness any two-legged ties, with the winner determined after just one game.