Cagliari took a surprise first-half lead through Jeda Capucho, but Milito scored on 51 and 55 minutes to win the game for Inter.

Five minutes after Milito's second, Inter boss Jose Mourinho was sent off for protesting.

Inter are third with 10 points, while Cagliari are second from bottom with a single point.

At Giuseppe Meazza, Clarence Seedorf scored the only to give AC Milan a 1-0 victory over Bologna.

Sampdoria ensured their leadership by thrashing Siena 4-1 at home to gain maximum points from the first four games.