The London side are now on top of the elite competition's table, two points ahead of second-placed United.
Portuguese veteran Deco believes that Drogba will give Chelsea superiority over the Red Devils in the pivotal game that could see Jose Mourinho's men widen the gap.
"The big difference between us and United is in attack," said Deco.
"Drogba is enjoying a spectacular moment in his career and is superior to the front-line of United.
"For me, Didi will be the key - the star of the match, for sure."
Four-point Value
"This match has a four-point value, an extra one for the blow to United's morale because they also failed to beat Liverpool.
"If they fail in London they will need to think very much about things in the following days.
"Victories in classic matches like this always have enormous value.
"For Chelsea to begin November with a five-point advantage over United will be sensational."