كتب : Sherif Tarek
A couple of own goals from Ronald Zubar Jody Craddock on 28 and 35 minutes respectively gave the Gunners a two-goal cushion.
Cesc Fabregas scored the third on the stroke of half time to leave the home side with a mountain to climb.
Andrei Arshavin further ensured Arsenal's superiority with a fourth goal two minutes past the hour mark.
Craddock netted a consolation goal for Wolverhampton one minute from time.
The London side now have 25 points, several goals ahead of third-placed Manchester United.
Defending champions United will face leaders Chelsea, who have 27 points, on Sunday.