كتب : Sherif Tarek
Dragutinovic slotted into his own net on the stroke of half time, and his side couldn't restore parity in the second half.
Sevilla, who have earlier booked their place in the next round, remain top of Group G on 10 points, while Romania's Unirea are now second with eight.
Elsewhere, Stuttgart kept their qualification hopes alive by recording a 2-0 win over Rangers.
Strikes from Sebastian Rudy and Zdravko Kuzmanovic on 16 and 58 minutes respectively gave the German side the vital win.
Now Stuttgart are third with six points, while Rangers remain bottom on two.
Stuttgart will clash with Unirea in their last game in the continental competition. The German side have to win to go through.