كتب : وكالات
Second-placed Real will miss in-form winger Cristiano Ronaldo and playmaker Kaka due to suspension and injury respectively.
"The important thing is to concern ourselves with those who are in the match," Emery told the pre-match press conference.
"Both teams have important players missing, but we intend to play and win."
Valencia will be without injured midfielder David Silva during Saturday's clash at the Mestalla.
Real are five points behind leaders and arch-rivals Barcelona, who played a game more due to their Club World Cup commitments.
Valencia, who won the last of their six league titles in 2004, are three points adrift of Real in third place.