كتب : وكالات
Swedish striker Ibrahimovic scored the winner as Barcelona defeated Real 1-0 in the first 'El Clasico' of the season at the Nou Camp in November but will not be able to play at the Bernabeu.
He is yet to recover from a calf injury he sustained in the warm up for last weekend's 4-1 victory over Athletic Bilbao.
Real, on the other hand, will miss Brazilian playmaker Kaka, who has been out of action since March 10 due to a thigh problem.
The outcome of the anticipated clash could play a key role in determining the league winner.
Defending champions Barcelona and arch-rivals Real are level on 77 points at the top.
If they remain tied on points after the match, the head-to-head record will separate them rather than goal difference.