كتب : وكالات
The visitors needed 17 minutes to open the scoring through a penalty from midfielder Axel Witsel.
Striker Jurgen Cavens brought Lierse level in the 30th minute but Mehdi Carcela-Gonzalez restored Standard's advantage seven minutes later.
The 21-year-old midfielder scored his second of the night on 70 minutes to widen the gap and Sebastien Pocognoli completed the rout three minutes from time.
Lierse's Egyptian winger Mohamed Abdul-Wahed was introduced as a second-half substitute after recovering from an injury.
His compatriot Dodo Al-Gabbas played the full 90 minutes and wasted a goalscoring opportunity in the 32nd minute.
There was no room for fellow Egyptian Ahmed Samir, who also missed Lierse's league opener.
The Egyptian-owned club kicked off their league campaign with a 1-0 defeat at Sint-Truiden last week.