The Congolese side, who had won their semi-final first leg with Kabylie 3-1, defended tightly to keep their two-goal lead intact.
Mazembe, who were crowned continental champions in 1967, 1968 and 2009 and finished runners-up in 1969 and 1970, will face the winning team from Sunday's semi-final clash between Ahli and Esperance.
The three-time African champions could have beaten Kabylie in the return leg as Jerome Damon pointed at the spot when one of their strikers was felled in the area.
However, the referee backtracked on his decision when the linesman raised his flag for offside.
Kabylie were reduced to ten men when Billel Naili received his marching orders on the hour mark for no apparent reason.
The hosts carved out a number of scoring chances throughout the match but couldn't convert any of them.