Second-division Bani Obeid caused an earth-shattering upset in 2008 when they ousted Cairo giants Zamalek from the very same stage of the competition.
The Mansoura-based club, who were in third tier when they beat Zamalek, will get another chance against the Whites in Cairo.
Holders Harras Hodoud were drawn against Hawamdia Sugar, whereas runners-up Ahli have got an easy challenge against third-tier Kima Aswan.
The competition is divided into two groups of 16 teams each as Ahli lead one and Hodoud top the other.
The FA has yet to announce the dates of the fixtures.
The full draw
Group A
Ahli vs. Kima Aswan
ENPPI vs. Rabat
Police Union vs. Toukh
Petrojet vs. Tanta
Gaish vs. Railways
Arab Contractors vs. Suez
Military Production vs. Bani Swaif
Ismaili vs. Kafr Al-Sheikh
Group B
Hodoud vs. Hawamdia Sugar
Zamalek vs. Bani Obeid
Wadi Degla vs. Fayoum
Gouna vs. Damanhur
Masri vs. Asyut Petroleum
MCDR vs. Nasr
Ittihad vs. Matrouh
Smouha vs. Sharqia