Ismaili face Kenyan minnows Sofapaka and Harras Hodoud play at Dedebit in the Confederation Cup on Saturday.
Zamalek V Club Africain
The Whites have the home advantage against Africain, however; their hopes of reaching the Champions League round of 16 are dented.
Hossam Hassan's side slumped to a 4-2 defeat at the Tunisian side in the first leg, which means they have to pull off a victory by at least a two-goal margin to stand a chance.
Zamalek strike duo Mohamed Amine Aoudia and Amr Zaki have been ruled out of the game through injury.
On the other hand, Africain skipper Wessam Ben Yehia is likely to be fit for the match after nursing an ankle problem.
SuperSport United V Ahli
Egyptian champions Ahli face SuperSport away with a two-goal advantage from the first leg.
South Africa's SuperSport were quite stubborn in the previous meeting and will be looking to cancel out the Red Devils' lead.
Ahli manager Manuel Jose warned his players off easing off in the match, calling on them to aim for another win.
Ahli midfielder Shehab Ahmed was once again left out whereas Ahmed Nabil 'Manga' was a surprise inclusion for the game.
Sofapaka V Ismaili
Ismaili lock horns with Sofapaka and are expected to go through. The Dervishes easily won the first leg 2-0.
However, some of the coastal side's players sounded a note of caution over the pitch of the hosts.
"The away matches in Africa always include difficulties regardless of the other team's level of performance," Ismaili right-back Ahmed Sedik told FilGoal.com.
"Usually, the pitch is uneven while the referee is biased towards the home side."